The first question is exposure. Air, water, food, work, and household products offer a more useful starting point than assuming that every symptom reflects a hidden toxin burden.
By Dr. Michele Burklund, NMD · Updated November 1, 2026
Begin with the question, then choose the test. Food, sleep, movement, connection, oral care, and relevant environmental changes remain the foundation. Laboratory work is most useful when a finding could change a decision.
01 / EXPOSURE HISTORY
Exposure History
Identify plausible sources and reduce ongoing exposure. Environmental assessment may answer a different question from measuring a chemical in the body.
02 / LIVER & KIDNEY CONTEXT
Liver & Kidney Context
Clinically appropriate blood and urine tests may assess organ function. They do not measure a general 'detox capacity' or prove that a supplement is clearing toxins.
03 / TARGETED METALS
Targeted Metals
Choose the specimen and assay for the suspected metal and exposure. Detectable levels do not necessarily establish toxicity. Provoked urine results cannot be compared with unprovoked reference ranges.
04 / PFAS
Pfas
PFAS blood testing can document selected compounds when exposure history supports a discussion. It does not identify the source or establish a treatment plan by itself.
The tests in this collection.
Quest Diagnostics
Heavy Metals Panel (Venous)
What it measures
Arsenic, lead, and mercury in venous blood.
Why it is here · When it may be useful
An occupational, household, dietary, or environmental history suggests exposure to one of the measured metals.
What ordering involves
Whole blood from a blood draw. Follow the instructions supplied with the exact order. Fasting and medication timing may change when tests are combined.
Keep in mind
Interpret with the reason for testing, symptoms, medical history, and the laboratory method. An isolated result is not a diagnosis.
Selected metals excreted in urine over a complete 24-hour collection.
Why it is here · When it may be useful
A specific exposure question requires assessment of metal excretion over a full day.
What ordering involves
Complete 24-hour urine collection using the laboratory container. Follow the exact start/stop and storage instructions. Incomplete collection affects results; do not add a chelation challenge.
Keep in mind
Excretion over one day is not total body burden. Recent exposures and specimen handling matter.
Selected environmental chemical metabolites in a urine specimen.
Why it is here · When it may be useful
A relevant exposure history supports a discussion about whether measured urinary chemical metabolites would change practical exposure reduction.
What ordering involves
Urine collected with the at-home kit. Use the RealTime Labs urine kit and its current collection, storage, and shipping instructions. Do not substitute blood-collection instructions.
Keep in mind
A spot urine finding reflects the substances measured and recent exposure or excretion. It does not establish total body burden, locate the source, or prove the cause of symptoms.
Arsenic, lead, and mercury in a random urine sample.
Why it is here · When it may be useful
The exposure history points toward arsenic, lead, or mercury and the selected specimen fits the clinical question.
What ordering involves
Random urine sample collected according to the order instructions. Follow the exact assay instructions and disclose recent seafood intake when arsenic is measured. Do not add a chelation challenge.
Keep in mind
Speciation may be needed to distinguish arsenic forms. Concentration and recent exposure affect urine findings; results are not a total toxin burden.
Use validated, unprovoked collection for metal evaluation. PFAS testing generally uses serum; follow the chosen laboratory's instructions.
Keep the limits in view.
A toxin result cannot by itself explain all symptoms. Chelator-challenge testing is not validated for diagnosing metal toxicity, and indiscriminate treatment can cause harm.
Results belong within your history, symptoms, examination, medications, and the laboratory's method. A reference interval is not a universal target for every person. There is no single validated set of 'optimal' values that applies across all assays and life stages.
Availability, ordering requirements, collection fees, and eligibility vary by test and location. Review the current Fullscript listing and your clinician's instructions before purchasing.
No. Choose a test only when its result may change a useful decision, taking existing results, symptoms and your budget into account.
Does an out-of-range result identify the root cause?
Not by itself. Interpretation depends on the assay, collection, history and the pattern across findings. A result can be one clue without being the explanation.
Where can I see ordering requirements?
Open the individual Fullscript listing for current availability, specimen instructions and eligibility. A collection may include alternatives rather than tests intended to be purchased together.